A method of preparing vicinal difluoro aromatic compounds in high yield from
hydroxy
aromatic compounds using various bases and a method of preparing intermediates
thereof. A method for making a vicinal difluoro halogenated aromatic compound including
providing a tetrafluoro derivative of a halogen substituted aromatic compound,
wherein the tetrafluoro derivative has two fluorine atoms on each of two adjacent
carbons and at least one additional halogen substituent; reacting the tetrafluoro
derivative with a reducing agent in presence of a base for a reaction time sufficient
to form the vicinal difluoro halogenated aromatic compound containing two vicinal
fluorine substituents and the at least one additional halogen substituent, wherein
the reducing agent is used in a reducing agent effective amount sufficient to retain
the at least one additional halogen substituent.
