The present invention provides recombinant yellow fever viruses (YFV), particularly
live attenuated recombinant YFV, which comprise exogenous (i.e., non-YFV) nucleotide
sequences which encode exogenous (i.e., non-YFV) amino acid sequences. These recombinant
YFV viruses comprise an exogenous nucleic acid. Infection of a host cell with a
recombinant YFV provides for expression of the exogenous nucleic acid in a host
cell and production of an antigenic polypeptide encoded by the exogenous nucleic
acid. Such recombinant YFV are useful in eliciting an immune response to the exogenous polypeptide.
