The present invention provides a method for treating a mammal with immunological
disorders, particularly autoimmune disease, and most preferably systemic lupus
erythematosus (SLE). The method includes oral administration of germination activated
Ganoderma lucidum spores ("GLSs") to the mammal. Additionally, a corticosteroid,
such as prednisolone, can be co-administered with the GLSs to the mammal to achieve
synergistic effect of treatment.
