A simulated moving bed connected with a sample supply apparatus is constructed
such that a sample liquid can be supplied continually to a simulated moving bed
separation device without causing any problems due to a penetration of gas phase
and admixture of the plurality of sample liquids. At this end, the sample supply
apparatus is composed of a plurality of sample supply vessels each with a sample
liquid passageway disposed thereto, a sample liquid-amount management vessel for
storing a sample to be supplied from the sample supply vessels through the sample
liquid passageways and the supplying sample liquid through the liquid-amount management
vessel to the simulated moving bed chromatographic device. The apparatus also has
a control for alternatingly opening and closing opening-closing devices in the
sample supply vessels in response to liquid levels in the sample liquid-amount
management vessel.
