The present invention provides compounds having formula (1): 1
and pharmaceutically acceptable derivatives thereof, wherein R.sup.1,
R.sup.2 and B are as described generally and in classes and subclasses
herein, and additionally provides pharmaceutical compositions thereof,
and methods for the use thereof for the treatment of any of a number of
conditions or diseases in which HGF/SF or the activities thereof, or
agonists or antagonists thereof have a therapeutically useful role.