Binding polypeptides comprising specific amino acid sequences are disclosed
that specifically bind ACE-2 protein or ACE-2-like polypeptides. The binding polypeptides
can be used in methods of the invention for detecting, isolating, or purifying
ACE-2 protein or ACE-2-like polypeptides in solutions or mixtures, or biological
samples. The invention also relates to nucleic acid molecules encoding these ACE-2
binding polypeptides, vectors and host cells containing these nucleic acids, and
methods for producing the same. The present invention also relates to methods and
compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating
a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression
or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding
polypeptides or fragments or variants thereof, that specifically bind to ACE-2.
