Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide
   
   

The present invention relates to new compounds of general formula ##STR1##

having thrombin-inhibiting activity. Exemplary are:

  • 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and
  • 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.

    		•
     
    Web www.patentalert.com

    < Serine protease inhibitors

    < Platelet ADP receptor inhibitors

    > Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants

    > Aminopyridyl-substituted phenyl acetamides as protease inhibitors
    ~ 00184