Transgenic flies displaying altered phenotypes due to expression of the
Abeta and C99 portions of the human APP gene are disclosed. Use of these flies
in a method to identify Drosophila genes and the human homologs of these
Drosophila genes, that are potentially involved in Alzheimer's Disease,
is also disclosed. The use of said human homologs as drug targets for the development
of therapeutics to treat Alzheimer's Disease and other conditions associated with
defects in the APP pathway, as well as pharmaceutical compositions comprising substances
directed to these genes, are also disclosed.
