A disease treatment is provided by controlling the expression of a protein induced
by a heat shock factor.
The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or
an inhibitor of inducing the production of a protein regulated by HSF, which inhibits
the activity of a heat shock factor, a transcriptional regulatory factor, thereby
in turn inhibiting transcription of a structural gene having a heat shock element
sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting
translation of the gene into a protein, and resulting in inhibition of inducing
production of RNA or protein encoded by the gene. It also provides a drug for treating
or preventing cancer through thermotherapy and a drug for treating or preventing
stress diseases such as depression.
