Compositions and methods are provided for the treatment of conditions
associated with cell proliferation, cell differentiation and cell survival. In
particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide
variants thereof that stimulate dephosphorylation of DSP-12 and DSP-13 substrates,
are provided. The polypeptides may be used, for example, to identify antibodies
and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and
agents may be used to modulate cell proliferation, differentiation and survival.
