Methods of treating disorders associated with elevated levels of PAI-1 are
disclosed comprising administering to a patient in need thereof a
therapeutically effective amount of at least one compound of formula at
least one compound of formula (I), 1
or a pharmaceutically-acceptable salt, prodrug, stereoismer or solvate
thereof, wherein:
A is aryl or heteroaryl, X is O or S, and R.sub.1-R.sub.9 and R.sub.18 are
defined herein. The invention also pertains to pharmaceutical
compositions and compounds within the scope of formula (I) as well as
medicaments and articles of manufacture comprising compounds of formula
(I).
