A conjugate of formula A-L-P, in which:
- A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor,
- L represents a bifunctional linker, which does not comprise a naturally
occurring amino acid and is covalently bonded to A and P in a regiospecific manner, and
- P represents a monomer, homopolymer or heteropolymer comprising at least
one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis
of nucleotides or nucleic acids in a sequence-independent manner,
- wherein either or both of the covalent bond between A and L and the
covalent bond between L and P can be cleaved intracellularly; a composition comprising
such a conjugate; and a method of inhibiting abnormal cellular proliferation in
a mammal; and a method of inhibiting replication of a virus in a mammal.
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