Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences
are characterized by containing at least one of an integrin binding motif such
as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif,
and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular
phosphoglycoprotein. The sequences may be formulated for injection or dispersed
in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth
growth and/or reduce excessive urinary phosphate loss from the body.
