The present invention is directed to compositions useful in treating or preventing
ileus in a patient. The compositions of the invention include a pituitary adenylate
cyclase activating peptide (PACAP) receptor antagonist and/or a vasoactive intestinal
peptide (VIP) receptor antagonist in an amount sufficient to treat or prevent ileus
in a patient. In one embodiment both a PACAP and VIP receptor antagonists are present,
preferably in a combination that blocks vasoactive pituitary cyclase 1 (VPAC1),
VPAC2 and pituitary adenylate cyclase 1 (PAC1) receptors. Methods of using such
composition to treat or prevent ileus in a patient are also encompassed by the invention.
