In certain embodiments, provided herein are compositions and methods for
increasing drug efficiency. The conjugates provided are in certain
embodiments, for compositions and methods in treatment of variety of
diseases and have the formula 1:
D-L-S (1)
or formula 2:
D-L-S' (2)
wherein D is a drug moiety;
L, which may or may not be present, is a non-releasing linker moiety;
S is a substrate for a kinase, other than a hexokinase, a protein kinase
or a lipid kinase; and
S' is a substrate for a phosphotransferase, other than a hexokinase, a
protein kinase or a lipid kinase.
