The invention provides for the identification of all genes, whether known or
novel, which are differentially expressed within and among B cells, making possible
the characterization of their temporal regulation and function in the B cell response
and/or in B cell mediated disorders. Expression profiles, nucleic acids and proteins
are provided for differing states of B cells, including resting, naive, activated,
tolerant and immunosuppressed B cells. The present invention makes possible the
identification and characterization of targets useful in prognosis, diagnosis,
monitoring, rational drug design, and/or therapeutic intervention of immune system disorders.
