Described herein are carbamate compounds. Such compounds are capable of
modulating the activity of a checkpoint kinase, and described herein are
methods for utilizing such modulation to treat cell proliferative
disorders. Also described are pharmaceutical compositions containing such
compounds. Also described are the therapeutic or prophylactic use of such
compounds and compositions, and methods of treating cancer as well as
other diseases associated with unwanted cellular proliferation, by
administering effective amounts of such compounds in combination with
anti-neoplastic agents.