A compound of the formula [I]
##STR1##
wherein R1 is optionally substituted aryl group or optionally
substituted heteroaryl group; R2 is optionally substituted C1-6
alkyl group, C3-7 cycloalkyl group and the like; R3 is hydrogen
atom, C1-6 alkyl group, hydroxyl group and the like; R4 is
hydrogen atom, C1-6 alkyl group and the like; R5 and R6
are each C1-6 alkyl group and the like; R7 is optionally
substituted aryl group or optionally substituted heteroaryl group; X1,
X2 and X3 are each C1-6 alkylene group and the
like; and X4 and X5 are each a single bond, methylene group
and the like, a salt thereof, a solvate thereof or a prodrug thereof, and a pharmaceutical
composition containing the compound, particularly a calcium receptor antagonist
and a therapeutic agent for osteoporosis, are provided. The compound of the present
invention is useful as a therapeutic drug of diseases accompanied by abnormal calcium
homeostasis, or osteoporosis, hypoparathyreosis, osteosarcoma, periodontal disease,
bone fracture, steoarthrosis, chronic rheumatoid arthritis, Paget's disease, humoral
hypercalcemia, autosomal dominant hypocalcemia and the like.
In addition, an intermediate for the compound is provided.
