The present invention provides improved methods, kits, and compositions for enhancing
bone, cartilage and cartilage repair, bone and prosthesis implantation, and attachment
and fixation of cartilage and cartilage to bone or other tissues, and chondrocyte
proliferation composing the administration of an effective amount of angiotensinogen,
angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin
II (AII), AII analogues, AII fragments or analogues thereof or AII AT2
type 2 receptor agonists.