A method of treating prostate cancer in a living mammal includes local administration
of a composition that includes a therapeutically effective concentration of collagenase.
In one embodiment, a method of treating prostate cancer in a living mammal includes
local administration of a composition that includes a therapeutically effective
concentration of collagenase and at least one of a glycosidase, a protease, a nuclease,
a lipase, an esterase, a plasminogen activator, a streptokinase, and combinations
thereof. Preferably a glycosidase, such as, for example, hyaluronidase, is administered.
Compositions used in methods for treating prostate cancer can also include or be
administered with calcium ions, a nonionic surfactant, such as, for example, Triton
X-100, and an antibiotic, such as, for example, gentamicin. Another method of treating
prostate cancer in a living mammal includes activating PSA in vivo by, for example,
locally administering calcium ions.
