Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline
carboxamide and naphthyridine carboxamide derivatives are described as inhibitors
of HIV integrase and inhibitors of HIV replication. These compounds are useful
in the prevention or treatment of infection by HIV and the treatment of AIDS, as
compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical
compositions, optionally in combination with other antivirals, immunomodulators,
antibiotics or vaccines. Methods of preventing, treating or delaying the onset
of AIDS and methods of preventing or treating infection by HIV are also described.
