This invention relates to compounds, compositions, and methods useful for
modulating polycomb group protein EZH2 gene expression using short
interfering nucleic acid (siNA) molecules. This invention also relates to
compounds, compositions, and methods useful for modulating the expression
and activity of other genes involved in pathways of polycomb group
protein EZH2 gene expression and/or activity by RNA interference (RNAi)
using small nucleic acid molecules. In particular, the instant invention
features small nucleic acid molecules, such as short interfering nucleic
acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA),
micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods
used to modulate the expression of polycomb group protein EZH2 genes,
such as EZH2.
