A compound, or a solvate or a salt thereof, of formula (I): 1
wherein, Ar is an optionally substituted aryl or a C.sub.5-7
cycloalkdienyl group, or a C.sub.5-7 cycloalkyl group or an optionally
substituted single or fused ring aromatic heterocyclic group;
R is C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylalkyl,
optionally substituted phenyl or phenyl C.sub.1-6 alkyl, an optionally
substituted five-membered heteroaromatic ring comprising up to four
heteroatoms selected from O and N, hydroxy C.sub.1-6 alkyl, amino
C.sub.1-6 alkyl, C.sub.1-6 alkylaminoalkyl, di C.sub.1-6 alkylaminoalkyl,
C.sub.1-6 acylaminoalkyl, C.sub.1-6 alkoxyalkyl, C.sub.1-6 alkylcarbonyl,
carboxy, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 alkoxycarbonyl C.sub.1-6
alkyl, aminocarbonyl, C.sub.1-6 alkylaminocarbonyl, di C.sub.1-6
alkylaminocarbonyl, halogeno C.sub.1-6 alkyl; or R is a group
--(CH.sub.2).sub.p-- wherein p is 2 or 3 which group forms a ring with a
carbon atom of Ar;
R.sub.1 represents hydrogen or up to four optional substituents selected
from the list consisting of: C.sub.1-6 alkyl, C.sub.1-6 alkenyl, aryl,
C.sub.1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido,
sulphonamido, C.sub.1-6 alkoxycarbonyl, trifluoromethyl, acyloxy,
phthalimido, amino or mono- and di-C.sub.1-6 alkylamino;
R.sub.2 represents a moiety --(CH.sub.2).sub.n--NY.sub.1Y.sub.2 wherein n
is an integer in the range of from 1 to 9, Y.sub.1 and Y.sub.2 are
independently selected from hydrogen; C.sub.1-6-alkyl; C.sub.1-6 alkyl
substituted with hydroxy, C.sub.1-6 alkylamino or bis(C.sub.1-6
alkyl)amino; C.sub.1-6-alkenyl; aryl or aryl-C.sub.1-6-alkyl or Y.sub.1
and Y.sub.2 together with the nitrogen atom to which they are attached
represent an optionally substituted N-linked single or fused ring
heterocyclic group;
R.sub.3 is branched or linear C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl,
C.sub.4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally
substituted single or fused ring aromatic heterocyclic group; and
R.sub.4 represents hydrogen or C.sub.1-6 alkyl; a pharmaceutical
composition comprising such a compound, process for preparing such a
compound and the use of such a compound in medicine.
