The present invention relates to compounds having the formula, 1
and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or
hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl,
pyridazinyl, pyrimidinyl, or pyrazinyl ring; R.sub.2 is alkyl or an amino
group as defined herein; and Z is optionally-substituted oxadiazolyl or
--C(.dbd.O)NR.sub.6, wherein R.sub.6 is lower alkyl or cyclopropyl. The
compounds are surprisingly advantageous in preparing pharmaceutical
compositions for treating p38 kinase related conditions and/or in methods
of treating conditions associated with the activity of p38 kinase in a
patient.
