2-O-(2-Methylthioethyl), has been incorporated
into oligonucleotides and evaluated for antisense properties in comparison with
the known 2-O-(2-methoxyethyl) 2-O-MOE modification. The 2-O-MTE
modified oligonucleotides exhibit improved binding to human serum albumin compared
with the 2-O-MOE modified oligonucleotides and maintain high binding affinity
to target RNA.
