The invention relates to compositions, such as pharmaceuticals, foods,
food additives, or dietary supplements, containing A-type procyanidins,
and methods of use thereof, for prophylactic or therapeutic treatment of
a human or a veterinary animal to treat or prevent NO-responsive health
conditions, treat hypertension, cardiovascular disease, coronary artery
disease and/or vascular circulation disorders, prevent or reduce the risk
of heart attack, stroke, congestive heart failure and/or kidney failure,
or to improve blood flow, for example renal blood flow. The composition
may optionally contain an additional NO modulating agent and/or a
cardiovascular-protective or therapeutic agent, or may be administered in
combination with such an agent.
