A rat model of diabetic nephropathy is disclosed. In another embodiment of
the invention, a method of evaluating a test compound's effect of
diabetic nephropathy is disclosed. In one embodiment, this method
comprises the steps of (a) exposing the test compound to the rat of claim
1, wherein the rat would develop progressive proteinuria and
glomerulosclerosis leading to diabetic nephropathy in the absence of the
test compound, and (b) comparing the rat's development of diabetic
nephropathy with a control T2DN mimic rat that has not been exposed to
the test compound.
