This invention relates to substituted 5-membered N-Herterocyclic
neurotrophic compounds of formula (I) or pharmaceutically acceptable
salts or hydrates thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, V,
W, X, Y, and Z are as defined in the description; their preparation
methods, compositions comprising the same, and their use as inhibitors of
FK560 binding proteases (FKBPs) activity for treating and preventing
neurodegenerative diseases and other nerve disorders associated with
nerve injuries or other related diseases. 1
