This invention concerns a compound of formula 1
a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine
and a stereochemically isomeric form thereof, wherein ring A represents a
6-membered heterocycle; R.sup.1 is hydrogen; aryl; formyl;
C.sub.1-6alkylcarbonyl; optionally substituted C.sub.1-6alkyl;
C.sub.1-6alkyloxycarbonyl; optionally substituted C.sub.1-6alkyloxyC.sub.-
1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or
S; R.sup.2 is hydrogen, C.sub.1-10alkyl, C.sub.2-10alkenyl,
C.sub.2-10alkynyl, a carbocycle or a heterocycle, each of said groups may
optionally be substituted; R.sup.3 is hydrogen; hydroxy; halo; optionally
substituted C.sub.1-6alkyl or C.sub.2-6alkenyl or C.sub.2-6alkynyl;
C.sub.1-6alkyloxy; C.sub.1-6alkylthio; C.sub.1-6alkyloxycarbonyl;
C.sub.1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or
di(C.sub.1-6alkyl)amino; polyhaloC.sub.1-6alkyl; polyhaloC.sub.1-6alkylox-
y; polyhaloC.sub.1-6alkylthio; R.sup.21; R.sup.21-C.sub.1-6alkyl;
R.sup.21--O--; R.sup.21--S--; R.sup.21--C(.dbd.O)--;
R.sup.21--S(.dbd.O).sub.p--; R.sup.7--S(.dbd.O).sub.p--;
R.sup.7--S(.dbd.O).sub.p--NH--; R.sup.21--S(.dbd.O).sub.p--NH--;
R.sup.7--C(.dbd.O)--; --NHC(.dbd.O)H; --C(.dbd.O)NHNH.sub.2;
R.sup.7--C(.dbd.O)--NH--; R.sup.21--C(.dbd.O)--NH--; --C(.dbd.NH)R.sup.7;
--C(.dbd.NH)R.sup.21; R.sup.4a or R.sup.4b each independently represent
hydrogen, R.sup.8, --Y.sub.1--NR.sup.9--Y.sub.2--NR.sup.10R.sup.11,
--Y.sub.1--NR.sup.9--Y.sub.1--R.sup.8, --Y.sub.1--NR.sup.9R.sup.10;
provided that --X--R.sup.2 and/or R.sup.3 is other than hydrogen; their
use, pharmaceutical compositions comprising them and processes for their
preparation.
