The present invention relates to piperidine derivatives of formula (I): 1
R represents halogen or C.sub.1-4 alkyl
R.sub.1 represents C.sub.1-4 alkyl;
R.sub.2 or R.sub.3 independently represent hydrogen or C.sub.1-4 alkyl;
R.sub.4 represents trifluoromethyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy,
trifluoromethoxy or halogen;
R.sub.5 represents hydrogen, C.sub.1-4 alkyl or C.sub.3-7 cycloalkyl;
R.sub.6 is hydrogen and R.sub.7 is a radical of formula (W): 2
or R.sub.6 is a radical of formula (W) and R.sub.7 is hydrogen;
X represents CH.sub.2, NR.sub.5 or O;
Y represents Nitrogen and Z is CH or Y represents CH and Z is Nitrogen;
A represents C(O) or S(O)q, provided that when Y is nitrogen and Z is CH,
A is not S(O).sub.q;
m is zero or an integer from 1 to 3;
n is an integer from 1 to 3;
p and q are independently an integer from 1 to 2;
and pharmaceutically acceptable salts and solvates thereof.
The process for their preparation and their use in the treatment of a
condition mediated by tachykinins.
