The invention provides compounds of the formula: ##STR1##

and pharmaceutically acceptable salts or prodrugs thereof, wherein m, p, q, r, A, E, X, Y, R¹, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹ and are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.