Arylpyrimidinone compounds that act as selective modulators of CRF
1 receptors are provided. These compounds are useful in the treatment of a number
of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular
disorders, and eating disorders. Methods of treatment of such disorders and well
as packaged pharmaceutical compositions are also provided.
Compounds of the invention are also useful as probes for the localization
of CRF receptors and as standards in assays for CRF receptor binding. Methods of
using the compounds in receptor localization studies are given.