This invention relates to a compound of the formula:
##STR1##
or a pharmaceutically acceptable salt thereof, wherein A and R1 are
each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl
is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is
NH2; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl
optionally substituted with halo and the like; and X1 to X4 are
each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted
with halo and the like. These compounds have COX-2 inhibiting activity and thus
useful for treating or preventing inflammation or other COX-2 related diseases.