The present invention provides a cyclic peptide comprising the structure:
##STR1##
wherein X is selected from the group consisting of an amino acid, an amino
acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the
group consisting of a synthetic amino acid and a biosynthetic amino acid, R is
selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is
0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide
comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH
and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein
X is selected from the group consisting of an amino acid, an amino acid analog,
a peptidomimetic and a non-amide isostere, Z is selected from the group consisting
of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is
1 to 10. Methods of preparation including a cyclization protocol, and methods of
use of the cyclic peptides of the invention are also disclosed.
