Corticotropin-releasing factor (CRF) antagonists having the formulae ##STR1##

wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.

 
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> 25312, a novel human agmatinase-like homolog

> Megakaryocytic protein tyrosine kinase I
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