Compounds having the formula (I),
##STR1##
and pharmaceutically acceptable salts or prodrugs thereof, are useful as kinase
inhibitors, wherein Y is —C(O)NR1—, —NR1C(O)—,
—NR1C(O)NR1—, —NR1SO2—,
—SO2NR1—, —C(O)—, —OC(O)—,
or —CO2—; B is alkyl, substituted alkyl, alkenyl, substituted
alkenyl, hydroxy, alkoxy, aryl, cycloalkyl, heteroaryl, and heterocyclo; or when
Y is —C(O)NR1—, B also may be selected from —C(O)R8,
—C(O)NR8R9, and —CO2R8;
R1 is hydrogen, C1-4alkyl, or substituted C1-4alkyl;
R2 is hydrogen or C1-4alkyl; R3 is hydrogen, methyl,
perfluoromethyl, hydroxy, methoxy, halogen, cyano, NH2, or NH(CH3);
and R4, R5, R6, R7, R8,
and R9 are as defined in the specification.