This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl
ICE/ced-3 family inhibitor compounds having the following structure:
##STR1##
wherein A, B, X, R, R1, R2, n, q, and r are as defined
herein. The invention is also directed to pharmaceutical compositions containing
these compounds, as well as the use of such compositions in the treatment of patients
suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention
of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.