Disclosed are methods and apparatus for isolating and driving a power supply or power amplifier circuit. The circuits and methods provide for using a modulated PWM input signal and its complement to drive one or more core-less transformers providing an isolated power supply circuit output signal reproducing the PWM input signal. Preferred methods of the invention are disclosed in which steps for receiving and modulating a PWM input signal and its complement are included. In further steps, the modulated PWM signal and its complement control an isolated output driver to provide a power supply circuit output signal reproducing the PWM input signal. Embodiments of the invention are disclosed in which a circuit is configured for receiving a PWM input signal, providing isolation, and outputting a PWM output signal. The circuits include modulators for modulating a PWM input signal and its complement. Pulse transformer stages deliver the modulated PWM signal and its complement to the respective gates of power transistors of gate driver output stages. At an output terminal, a PWM output signal responsive to the PWM input signal is produced.