The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38.alpha. MAP kinase and/or HMG-CoA-reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.

 
Web www.patentalert.com

< 3-(3,5-Disubstituted-4-hydroxyphenyl)propionamide derivatives as cathepsin b inhibitors

< Novel thyroid receptor ligands and method II

> Lactam tachykinin receptor antagonists

> Histone deacetylase inhibitors based on alpha-ketoepoxide compounds

~ 00227