The invention provides methods, therapeutics and kits for treating and
preventing diseases or conditions associated with excessive lipolysis, in
particular TNF-.alpha. induced lipolysis, and/or excessive free fatty
acid levels. Exemplary conditions include insulin-resistance, diabetes,
in particular NIDDM, obesity, glucose intolerance, hyperinsulinemia,
polycystic ovary syndrome, and coronary artery disease. In a preferred
embodiment, the method includes administering to a subject in need a
pharmaceutically effective amount of an inhibitor of the JNK signal
transduction pathway and/or an inhibitor of the MAPK/ERK signal
transduction pathway.
