The present invention provides an inhibitor of NF-.kappa.B, guggulsterone and its analogs. Guggulsterone suppresses NF-.kappa.B activation induced by TNF, phorbol ester, okadaic acid, cigarette smoke, H.sub.2O.sub.2 and IL-1.beta., as well as constitutive NF-.kappa.B activation expressed in most tumor cells. One mechanism by which guggulsterone inhibits activation of NF-.kappa.B is through suppression of I.kappa.B.alpha. phosphorylation and I.kappa.B.alpha. degradation. NF-.kappa.B-dependent gene transcription is modulated by guggulsterone and its analogs. In particular, induction by TNF, TNFR1, TRADD, TRAF2, NIK and IKK, is modulated by guggulsterone and its analogs. In addition, guggulsterone decreased the expression of genes involved in anti-apoptosis (IAP1, XIAP, Bfl-1/A1, bcl-2, cFLIP, survivin), proliferation (cyclin D1, c-myc) and metastasis (MMP-9, COX2 and VEGF).

 
Web www.patentalert.com

< Mental and physical health status monitoring, analyze and automatic follow up methods and its application on clothing

< Novel human G-coupled protein receptor kinases and polynucleotides encoding the same

> Methods for treating and preventing insulin resistance and related disorders

> RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
~ 00234