An apparatus and device for dispensing femtoliter to nanoliter volumes of liquid
samples are disclosed. The apparatus includes a liquid-support plate, two electrodes,
a substrate, and a control unit. The liquid support plate has a plurality of liquid-support
regions, each capable of supporting a liquid meniscus thereon. The first electrode
contains a plurality of electrode connections, each operatively connected to one
of the liquid support regions, for electrical contact with a meniscus supported
in such region. The substrate has a first side confronting the plate and an opposite
side, and a plurality of sample-holding regions formed in the first side. The second
electrode is disposed adjacent one of the two substrate sides. Thus, a selected
volume of the liquid can be ejected from or to one or more of the liquid-support
regions to or from one or more of the sample-holding regions.