This invention relates to a new and distinct variety of strawberry named 'Driscoll Sanibel.' The variety is similar to the varieties 'Biscayne' and 'Key Largo.' The variety is distinguished from 'Biscayne' and 'Key Largo,' in particular, by its smaller number of teeth on the terminal leaflets, longer fruit length, greater number of achenes per berry, greater average fruit yield, flat terminal leaflet margin profile, and moderate resistance to Verticillium.