A tissue ablation system is described that generates a uniform avascular plane of coagulated tissue to aid in the bloodless or near-bloodless resection of various biological tissues from a variety of organs. The tissue ablation system includes an energy director guide and two or more sets of bipolar energy directors. The energy director guide includes a series of channels that configure the energy directors to provide approximately uniform power distribution or current density through a target tissue volume or plane. The spacing among the channels of the energy director guide varies according to the total number of energy directors received in the energy director guide so that relative spacing among the center-most channels is largest and relative spacing among the end-most channels is smallest. The energy director guide secures a selected position of each of the energy directors in the target tissue volume.