A game call system includes a mouthpiece that produces sound by a plurality of reed or membrane portions vibrating against or near a plurality of sound-producing surfaces. Preferably, the game call has two recessed or curved or contoured surfaces on two halves of a generally circular end of the mouthpiece, with an aperture between the two curved/contoured surfaces. These surfaces may be identical, substantially identical, or different, and the reeds or reed portions also may be identical, substantially identical, and or different. Air passes over the reed(s) to create vibrations in the reed(s), and the resulting sound waves pass through the center aperture of the mouthpiece into the resonating chamber of the call, and through any resonating tube or other member that may optionally be present. The multiple sound-producing regions allow for more complex and/or realistic sounds than conventional single sound-producing region and single reed calls.