Quinolone carboxylic acid derivatives of formula (I) and pharmaceutically
acceptable salts thereof have potent antibacterial activity:
##STR1##
wherein,
- R1 is a C1-4 alkyl group, or phenyl or C3-6
cycloalkyl group optionally substituted with one or more halogens;
- R2 is H, amino or C1-4 alkyl group;
- R3 is H, C1-4 alkyl group, or amino, aminomethyl
or aminoethyl group optionally substituted with one C1-4 alkyl radical;
- W is N, CH or CY (Y is halogen, or C1-4 alkyl or C1-4
alkoxy group optionally substituted with one or more halogens); and
- Pyr represents 2-, 3- or 4-pyridyl group,
- provided that when W is C, W and R1 are fused together to
form COCH2CH(CH3), CCH2CH2CH(CH3),
or CSCH2CH(CH3).
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