The present invention provides compositions of matter which allow for the extended
release and enhanced bioavailability of biologically-active polypeptides following
parenteral delivery to an animal. More particularly, it concerns compositions comprising
biologically-active somatotropin formulated for extended release, methods of preparing
these compositions, and methods of using the same. These compositions comprise
somatotropin, a pH-adjusting constituent (PAC), and a substantially non-aqueous,
hydrophobic excipient. The PAC may comprise any suitable, biocompatible compound
including, but not limited to one or mixtures of two or more of the following:
acetic acid, phosphoric acid, monobasic phosphate. The PAC is added to the compositions
of matter in an amount effective to adjust the pH to or near to the isoelectric
point (pI) of the somatotropin component.