An interactive occlusion system, including software and hardware, for the treatment of amblyopia using virtual reality or other physically interactive or perceptually immersive three-dimensional or two-dimensional computer generated simulations, in which the patient's occlusion compliance and usage time during occlusive and non-occlusive periods can be precisely recorded and the patient's visual acuity can be accurately measured to be provided to the clinician, as well as the capacity for entering prescriptions and treatment plans for individual patients and restricting individual access to that patient's prescription and treatment plan while allowing non-occlusive operation of the system after the prescribed occlusion time or for non-patient users.