A cotton cultivar, designated DP 6226 BG/RR Acala, is disclosed. The invention relates to the seeds of cotton cultivar DP 6226 BG/RR Acala, to the plants of cotton DP 6226 BG/RR Acala and to methods for producing a cotton plant produced by crossing the cultivar DP 6226 BG/RR Acala with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar DP 6226 BG/RR Acala with another cotton cultivar.