The subject invention provides novel peptides for use in treating mammals to
control appetite and obesity. Disclosed is a peptide derivative having the formula:
X1-Z-Q-arg-trp-NH12
- wherein: X1 is an acyl group, Z is amino-2-naphthyl-carboxylic
acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically
acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4
receptor agonist activity.
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